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Graft, Vol. 5, No. 4, 237-249 (2002)
© 2002 SAGE Publications

Effective Immune Transfer, along with Induction of Rejection, Are Consequences of Using Grafts from Highly Immunized Donors

U. Dahmen

Klinik und Poliklinik

T. Tanigawa

Klinik und Poliklinik

L. Doebel

Klinik und Poliklinik

S. Polywka

Klinik und Poliklinik

O. Dirsch

Klinik und Poliklinik

J. Li

Klinik und Poliklinik

S. L. Jensen

Klinik und Poliklinik

A. Frilling

Klinik und Poliklinik

C. E. Broelsch

Klinik und Poliklinik

Adoptive transfer of immunity has recently been proposed as a new strategy to preventor treat hepatitis B infection in bone marrow graft recipients. However, although immunetransfer by clinical organ transplantation has been observed only occasionally, it has ledto severe complications in the recipient. The authors aimed to investigate the potentialrisk and benefit of adoptive immune transfer from donor to recipient after rat liver transplantationin a spontaneously tolerant model (BN->LEW). Using liver grafts from highlyimmunized donors (sensitized by 4 repeated nonspecific skin grafts), lethal rejectionwas induced in 40% (6/15) of the recipients compared with a rejection rate of 50%(13/26) after single nonspecific sensitization of the recipients. Transfer of donor-derivedcellular immunity was shown by the accelerated rejection of an AxC 99235 Irish rat (ACI)skin graft. LEW recipients of a liver graft from an ACI-skin-sensitized BN donor rejectedthe challenged skin graft in 10.4±0.5 days ( n = 5), compared with the control group(13.5±2.1 days, n = 8, P < 0.05). Transfer of donor-derived humoral immunity wasdemonstrated in all animals in both models-donor sensitization as well as donor vaccination.In conclusion, adoptive transfer of immunity by liver transplantation seems tooccur uniformly after liver transplantation, independent of the immunization protocol. Usingorgans from highly immunized donors potentially puts the recipients at the risk of enhancingongoing rejection.

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