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Graft, Vol. 5, No. 3, 128-131 (2002)
DOI: 10.1177/1522162802005003002
© 2002 SAGE Publications

Successful Conversion of Immunosuppressives from Cyclosporine to Tacrolimus in Chronic Rejection after Kidney Transplantation

Cornelia Blume

Markus Hollenbeck

Katrin Ivens

Peter Heering

Gerd-Rüdiger Hetzel

Bernd Grabensee

The persistence of chronic renal allograft nephropathy is an important cause of graftloss. Here the authors describe the 1st long-term results after switching from cyclosporinA (CyA) to tacrolimus in patients with chronic allograft nephropathy. Eighteenpatients had chronic allograft nephropathy confirmed by biopsy. Mean observation periodwas 12.3 months. The mean rate of decline in glomerular filtration (1/serum creatinine x?100/year) was measured as a function of time before and after conversion therapyusing linear regression analysis. The regression coefficients were compared usingthe Student t-test for paired samples. Conversion to tacrolimus significantly reduced theprogression to kidney failure. Kidney function was stable in the observed time intervalas the mean change of glomerular filtration rate decelerated significantly (1/creatinineper year x 100, P< 0.029). Lipids and blood pressure values were significantly loweredafter conversion therapy. The authors' results suggest that switching from CyA totacrolimus is adequate for treating chronic rejection in kidney allograft recipients.

Key Words: acute and chronic kidney allograft refection • hypertension • conversion treatment • serum lipids • Tacrolimus (FK 506) • blood pressure

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