Advanced Search

Journal Navigation

Journal Home



Contact Us

Table of Contents

Click here to register today!

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yin, D.
Right arrow Articles by Chong, A. S.
Right arrow Search for Related Content
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Graft, Vol. 5, No. 1, 27-33 (2002)
© 2002 SAGE Publications

Transplantation Tolerance: Of Mice and Men

Dengping Yin

Rush-Presbyterian-St. Luke's Medical Center

Ian A. Boussy

Rush-Presbyterian-St. Luke's Medical Center

Anita S. Chong

Rush-Presbyterian-St. Luke's Medical Center

Most strategies that successfully induce transplantation tolerance in murine models have failed upon translation into clinical therapies, and transplantation tolerance remains an elusive clinical goal. The disparity in outcome between mouse and human studies has led some investigators to cynically question whether data on tolerance in mice have any relevance to humans. The authors believe that this cynicism is overly negative and that principles of immune tolerance in humans can be revealed with mouse models. In this review, the authors discuss why the lessons of transplantation tolerance learned from mice have not directly translated into large animals, and how to overcome this problem.

Key Words: tolerance • organ transplantation • rodents • bone • costimulation

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?